![]() Formula SNEDDS terdiri dari cremophor RH 40 sebagai surfaktan, propilen glikol sebagai ko-surfaktan, Virgin Coconut Oil (VCO) sebagai fase minyak dan EPMS sebagai zat aktif. ![]() P>Penelitian ini bertujuan untuk menentukan formula Self-Nanoemulsifying Drug Delivery System (SNEDDS) menggunakan zat aktif etil-p-metoksisinamat (EPMS). The identification results show that OPMC can be synthesized by both of method with optimum reaction time for esterification method is 3 hours and for transesterification method is 5 hours. The OPMC synthesis results were identified with TLC, FTIR spectrophotometry, and gas chromatography-mass spectrometry (GC-MS). In the transesterification method, EPMC directly reacted with octanol in different reaction time (2,3,4,5,6 h). In the esterification method, EPMC was hydrolysis into 4-methoxycinnamic acid (4-MCA) (72%) then reacted with octanol in different reaction time ((2,3,4,5,6 h). The first step is the extraction of EPMC from kaempferia galanga L. The purpose of this study is to compare the synthesize of OPMC from natural EPMC by esterification and transesterification method. OPMC can be synthesized from ethyl p-methoxycinnamate (EPMC) as main contain in kaempferia galanga L. ![]() Octyl p-methoxycinnamate (OPMC) is a cinnamic acid derivative that is often used for sunscreens in cosmetics.
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